Drury Inn & Suites Sikeston

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2608 E Malone Ave
Sikeston, MO 63801
Travel Happy® with free hot breakfast, 5:30 Kickback® with dinnertime snacks and cold drinks, Wi-Fi, popcorn and soda, a business center, a workout facility, and more. A microwave and refrigerator can be found in all rooms. Drury Hotels is 100% family-owned and operated. At every one of our 150+ locations in 26 states, you'll consistently experience rooms with crisp sheets, fine linens, and cozy surroundings to ensure a good night's sleep.

Reviews

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4.039 reviews
Photo of Adrienne J.
Adrienne J.
9/3/2025

Last minute reservation as we traveled home from florida. Beautiful room, comfortable beds and clean. Morning reservation/front desk crew Amazing! Our new go-to hotel

Photo of Alyssa S.
Alyssa S.
11/28/2025

Loved our stay at the Drury Inn. We were greeted warmly upon our arrival. The lobby area was very warm and welcoming. Our room was very clean, well lit and cozy. The beds were comfortable as...

Photo of Nichole M.
Nichole M.
1/2/2025

I enjoy staying at the Drury INN when I travel. They have excellent customer service (by Laurie), the establishment is well decorated, there is plenty of parking, they have a bottle refill...

Photo of Richard B.
Richard B.
4/11/2024

Having lived in Europe for the past 30+ years, I had not heard of Drury Hotels. I booked a room for two nights in Sikeston, Missouri. My goodness was I in for surprise. The Drury inn and suites...

Photo of Vickey H.
Vickey H.
5/13/2025

We absolutely loved our stay at Drury Inn & Suites. So clean and at a very reasonable price! We will book with Drury Inn whenever possible.

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