John Sperati, MD

Dr. C. John Sperati is an Associate Professor of Medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include renal medicine. Dr. Sperati is Director of the Glomerular Diseases Fellowship Program since 2023 and formerly directed the Nephrology Fellowship Training Program from 2019 - 2025. He was the long-serving Firm Faculty Leader of the Barker Firm and has held leadership positions within the Osler Medical Residency training program. In addition, he co-directs the Johns Hopkins Osler Learning Initiative which brings the principles of medical residency training to executive education worldwide. He obtained his medical degree from The Pennsylvania State University College of Medicine and a Master in Health Science from the Johns Hopkins Bloomberg School of Public Health. He completed an internship and residency in Internal Medicine at the Johns Hopkins Hospital, followed by a year as an Assistant Chief of Service (chief resident). He subsequently pursued subspecialty training in nephrology at the Johns Hopkins Hospital and joined the faculty in the Division of Nephrology. Dr. Sperati’s clinical interests are in thrombotic microangiopathy including atypical hemolytic uremic syndrome (aHUS), complement-mediated kidney diseases including C3 glomerulopathy, glomerular disease such as glomerulonephritis (e.g., IgA nephropathy, MPGN) and nephrotic syndromes (e.g., FSGS, membranous, minimal change, amyloidosis, and others), and secondary and resistant hypertension (e.g., fibromuscular dysplasia, atherosclerotic renal arterial disease, hyperaldosteronism, and genetic hypertensive syndromes). He is the site principal investigator for clinical trials in glomerular disease, serves on editorial boards, and chairs the approval committee of the Longitudinal Knowledge Assessment for nephrology for the American Board of Internal Medicine. His clinical acumen and educational contributions have been recognized by induction into the Miller Coulson Academy of Clinical Excellence as well as the American Society of Nephrology Distinguished Educator Award in 2020. He has been recognized as a physician resource through the Atypical HUS Foundation, a NephCure glomerular disease specialist, an IgA Nephropathy Foundation specialist, and a Baltimore TopDoc. He is registered with the Florida Department of Health to perform telehealth services for patients in Florida.