Chad Barrett Crigger, MD

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200 N Wolfe St Lowr
Baltimore, MD 21287
Chad Crigger, M.D., M.P.H., is a pediatric urologist at Johns Hopkins Children’s Center and an assistant professor of urology at the Johns Hopkins Brady Urological Institute. He also serves as the Associate Program Director of the Urology Residency Program. After growing up in Charleston, West Virginia, Dr. Crigger attended the University of Richmond, where he majored in biology. After college, he returned home to West Virginia and obtained his medical doctorate from Marshall University and a master’s in public health from West Virginia University. He then completed an internship in general surgery and a residency in urologic surgery at West Virginia Ruby Memorial Hospital, where he was drawn to pediatric urology, particularly the reconstructive aspects that draw on principles from several fields including pediatric plastic surgery. This, and a chance visiting professorship by John Gearhart, M.D., inspired Dr. Crigger to pursue training in major reconstructive pediatric urology at Johns Hopkins, where he completed a fellowship. Relying on his background as a camp counselor, Dr. Crigger makes his patients active participants in their care whenever possible, often through sketching their condition. He is a member of multiple professional societies, including the American Urological Association and the American College of Surgeons. A researcher and director of pediatric urology research, he has published more than 50 articles in major journals and contributed to over 20 book chapters on pediatric urology. Dr. Crigger’s research focuses on his passion for major congenital anomalies, particularly the exstrophy-epispadias complex, about which he has multiple projects spanning the basic and clinical sciences. Additionally, with extensive training in robotic surgery, Dr. Crigger serves as director of robotic surgery for pediatric urology. His team looks for ways to safely apply the robotic surgery platform, including single port surgery, when feasible. His philosophy in practicing medicine is simple: to “provide the greatest benefit through the most up-to-date and least morbid treatment options possible.” Regarding providing care for patients and working with families, his focus is singular. When talking with parents, he can often be heard saying, “I know that, whether I am performing surgery or offering my professional recommendation, I am caring for one of the most important people in your life. I take that responsibility seriously and will do my very best to deliver the highest level of care possible.”
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David J. Hackam, M.D., Ph.D., is the Garrett Family Professor of Pediatric Surgery at The Johns Hopkins University, and Pediatric Surgeon-in-Chief and co-Director of the Johns Hopkins Children’s Center.Dr. Hackam’s clinical practice focuses on complex neonatal surgery. As pediatric surgeon in chief and co-director of the Childrens Center, Dr. Hackam oversees all perioperative clinical operations that involve children, with a strong emphasis on quality and safety, programmatic growth, and system alignment.Dr. Hackam's research is focused on unraveling the mechanisms of necrotizing enterocolitis, which is the leading cause of death in premature infants from gastrointestinal disease. His work has identified a series of novel pathways that, in response to the abnormal microflora that characterizes the premature intestine, leads to intestinal mucosal barrier breakdown, bacterial translocation, mesenteric vasoconstriction, and NEC. In seeking to translate these findings to clinical studies, we have developed a family of molecules that can prevent NEC development, and which have in part been licensed for clinical development. In additional work, Hackam has developed a prototype artificial intestine, derived from patient-specific intestine stem cells, which we have implanted into pre-clinical models, for the treatment of short bowel syndrome, a devastating complication of NEC. Finally, using single-cell RNA-seq and cell tracking technology, Hackam has worked towards understanding and treating NEC-associated brain injury, a major complication of NEC, and has engineered nanoparticle-packaged molecules that can cross the blood-brain barrier, and reverse the processes that lead to this disease. These studies are funded by three ro1s, a T32, a MIRA (a maximizing investigators’ research award) and 3 industry grants from companies with an interest in NEC treatment and prevention. Dr. Hackam seeks to work with industry partners, as well as nurses, doctors, and families of patients around the country, in order to develop novel regimens to safely and effectively deliver appropriate nutrition to the most vulnerable infants, who are at risk for the development of intestinal disease.
United StatesMarylandBaltimoreChad Barrett Crigger, MD

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