Jeannine M.
12/18/2025
Did not disappoint! Was told I had to go here on my trip to NOLA. I read the other reviews which helped me to decide what to order and it was delicious! Staff was very good and patient. Worth...
Domilise Po-Boys & Bar
$
Closed
(758)
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5240 Annunciation St
New Orleans, LA 70115
Domilise's Po-Boys and Bar, established in 1918, is a cherished fixture in the Uptown neighborhood of New Orleans. The family-owned establishment is renowned for its delectable po-boys, serving the community with a dedication to tradition and exceptional hospitality spanning generations.
The legacy began with Peter and Sophie Domilise, later nurtured by Dorothy "Miss Dot" Domilise and her family, who continue to welcome both locals and tourists alike as part of their family. Through the highs and lows of New Orleans history, Domilise's has remained a beloved haven where memorable meals and enduring kinship thrive.
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Reviews
4.0(758)
Bill W.
12/9/2025
If you like to experience local culture while enjoying local cuisine, you're going to love Domilise's. As you walk through the front door you feel like you've been transported to another time. A...
Lynne T.
12/24/2025
Greattttt service! Had a short wait time. Ordered small fried shrimp poboy and husband ordered half-half oyster and shrimp. The bread loaf was extra crunchy with tiny shrimp. Not my favorite...
Florence T.
12/8/2025
I'm surprised I hadn't heard of this location until my family invited me to meet them here. It's a cute place in Uptown. We grabbed a spot outside and went inside to order. The space is fairly...
Brad R.
11/12/2025
TLDR: A classic New Orleans spot serving some of the best po-boys in the city. Worth the wait every single time. Domilise's Po-Boys & Bar is a true New Orleans staple that's been serving...
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