Zest

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4500 San Pablo Rd S
Jacksonville, FL 32224

Zest at Mayo is a culinary venture created by local chefs and brothers Matthew and David Medure, located within the Mayo Building Atrium of the Jacksonville Mayo Clinic. This family-owned establishment offers a diverse menu featuring breakfast, lunch, and dinner, along with a convenient grab-and-go market for fresh salads, sandwiches, and protein bowls.

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4.542 reviews
Photo of Denise D.
Denise D.
10/16/2025

Always consistently friendly and pretty fast at getting orders up. I tried the pumpkin white mocha latte today. It was okay, not as sweet as I usually like, but I didn't ask which of the fall...

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Karen B.
12/4/2025

Great little cafe within Mayo Clinic fairly close to the Emergency Department with tasty breakfast and lunch options. Muffins, a variety of egg sandwiches, ready to go lunch sandwiches and salads,...

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MaryLou B.
5/19/2025

I had an early morning appointment and I know traffic is crazy in the morning around Mayo Clinic. The hubby and I arrived early because we knew that Zest would offer us a delicious breakfast. I...

Chris I.
1/2/2026

Stale Danish, might have been fresh 2 days ago! I asked for a short capuccino but got a large cup filled to the brim. Wishy-washy and watery. Very disappointed as my last visit was mu h better

Photo of Kelly B.
Kelly B.
8/20/2024

Service with a smile and ran like a well oiled machine. I don't know whose mama makes these grits but wow! So thick, creamy and yummy! They do need salt and pepper but don't need butter. This...

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