Elizabeth P.
10/19/2025
We ordered from the specials: short ribs and the mole enchiladas. Both were outstanding. Nice ambiance on a Sunday evening with live music. Lots of interesting decor. This place seems really...
The Guadalupe on Main
$$
Closed
(225)
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1526 E Main St
Mesa, AZ 85203
The Guadalupe on Main in Mesa, AZ, offers a craft kitchen and cocktail experience on Main Street. Specializing in flavors from Jalisco, the restaurant provides a gluten-free friendly Mexican menu, inviting guests to savor authentic dishes.
With a focus on quality ingredients and innovative recipes, The Guadalupe on Main aims to create a unique dining experience for patrons seeking a taste of traditional Mexican cuisine with a modern twist.
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Reviews
4.5225 reviews
Michelle S.
11/8/2025
Guadeloupe on Main delivered a standout family-run dining experience. Our server, who also happened to be the chef's brother, set the tone immediately with warm, genuine hospitality that matched...
Savannah R.
11/23/2025
Okay..WHAT is this hidden gem?! If you haven't been here, stop what you're doing and get over here now. Guadalupe on Main is a Sonoran style Mexican food spot giving off upscale moody upscale...
Andrea W.
10/31/2025
Gluten free eater here. This is really good Mexican food. Most places I have to pick and chose what I eat because of my gluten intolerance. Most everything on this menu is gluten free (except the...
Denise K.
11/29/2025
The Guadalupe on Main is a beautifully decorated Mexican restaurant. Some dishes were stronger than others, but a few truly stand out--the mole enchiladas and the birria tacos. Pass on the shrimp...
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